This workshop will provide new insights into the basic, translational, and clinical aspects of chemotherapy-induced peripheral neuropathy (CIPN) and explore translation and failures. Recognizing the importance of people living with CIPN, Fiona Talkington, BBC broadcaster, will co-chair the session and give the view of someone with lived experience.  Dr. Lesley Colvin will discuss the current clinical state of CIPN; the clinical and research challenges the field faces, and the emerging scientific opportunities to find effective therapeutics for CIPN. Second, Dr. Peter Grace will describe how histone deacetylase 6 (HDAC6) inhibitors have therapeutic potential to reverse cisplatin-induced neuropathic pain via enkephalin-delta opioid receptor signaling in peripheral sensory neurons in a rodent model. And third, co-chair Dr. Alfonso Romero-Sandoval will provide translational evidence on how an endoplasmic reticulum stress sensor (IRE1a/XBP1) in circulating immune cells, correlates with neuropathy severity in cancer patients with CIPN, as predicted by preclinical studies.