This workshop will give an overview of recent developments in pre-clinical models of nerve injury and neuropathic pain. We will highlight the latest mechanistic findings obtained with cutting-edge technologies, improved animal models and interdisciplinary know-how. Specifically, we show evidence from 2-photon imaging that abnormal re-innervation patterns could contribute to the emergence of neuropathic pain. We will present findings on innate and adaptive immune cell dysregulation locally, within nerves, some of which persists over very long periods of time. And finally, we will present a novel translational model for pain after nerve crush. 

By the end, attendees will have gained an idea of what we have learned in the past few years about persistent local inflammation and neuron dysfunction in animal models of neuropathic pain.