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International Association for the Study of Pain

Acute cold hypoesthesia indicates future central post-stroke pain - FR61

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Abstract Description

Institution: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany - Germany, Deutschland

Central post-stroke pain (CPSP) is a severe and treatment-refractory type of neuropathic pain. It can occur within weeks to months after a cerebrovascular injury and is one of the worst outcomes of somatosensory stroke. It remains unclear, what distinguishes patients who will develop CPSP from those who will not, in the following referred to as non-pain sensory stroke (NPSS) patients. In our study, we address the need of a prospective quantitative sensory testing (QST) analysis of sensory profiles in patients with acute somatosensory stroke. We show that already in the early stage after stroke, CPSP patients showed a cold hypoesthesia compared to NPSS patients, indicating a cold perception deficit in patients who will later develop pain. Our findings allow an early detection of patients at risk for CPSP permitting rapid therapeutic intervention to prevent pain chronification. 

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Susanna Asseyer - Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany , Eleni Panagoulas - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Berlin School of Mind and Brain and MindBrainBody Institute at Humboldt-Universität zu Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin , Jana Maidhof - DRK Klinikum Köpenick, Berlin, Germany , Esra Al - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Columbia University New York; USA , Xiuhui Chen - Berlin School of Mind and Brain and MindBrainBody Institute at Humboldt-Universität zu Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin , Kersten Villringer - Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany , Thomas Krause - Department of Neurology, Jewish Hospital Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany , Arno Villringer - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Berlin School of Mind and Brain and MindBrainBody Institute at Humboldt-Universität zu Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin , Gerhard Jan Jungehülsing - Department of Neurology, Jewish Hospital Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany

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