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International Association for the Study of Pain

Cellular and Molecular Plasticity Biomarkers for the Natural Resolution of Neuropathic Pain in Rat DRG and their Gender-Specificity - FR92

Posters

Abstract Description

Institution: University Hospital Würzburg - Bavaria, Deutschland

Chronic Constriction Injury (CCI) of the sciatic nerve is a commonly used model to investigate molecular and cellular mechanisms in neuropathic pain with natural pain resolution over time. Here, we hypothesize that resolution of pain depends on multicellular interaction and plasticity of neurons, satellite glial cells and local macrophages within the dorsal root ganglia (DRG). In this study, we compare molecular and cellular plasticity in the DRG of female and male rats at maximal mechanical hypersensitivity with a time point of partial improvement of the behavioral phenotype. 

Presenters

Authors

Authors

Felicitas Schlott - Department of Neurology, University Hospital Würzburg , Dr. Annemarie Schulte - Department of Neurology, University Hospital Würzburg , Dr. Beate Hartmannsberger - Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine; University Hospital Würzburg , Dr. Annemarie Aue - Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine; University Hospital Würzburg , Prof. Dr. Alexander Brack - Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine; University Hospital Würzburg , Prof. Dr. Heike Rittner - Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine; University Hospital Würzburg , Prof. Dr. Robert Blum - Department of Neurology; University Hospital Würzburg

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