One-third of fibromyalgia patients describe their symptoms as neuropathic-like pain quality, and the reduced density of intraepidermal nerve fibre and fibres C hyperexcitability observed in fibromyalgia patients could explain the dysesthesia observed in a patient's subset. Therefore, we wondered whether small fibre dysfunction might also occur and impact pain observed in the reserpine-induced fibromyalgia experimental model, thus confirming its construct validity. Several parameters characteristic of neuropathic pain, such as mechanical allodynia, cold allodynia, heat hypersensitivity, anxiety-like behaviour, and depressive-like behaviour, were observed similarly in male and female mice submitted to the reserpine-induced fibromyalgia model. Reference drugs for both pathologies, fibromyalgia and neuropathic pain (pregabalin and duloxetine) attenuated these symptoms. However, the model did not alter the PGP9.5-positive intraepidermal nerve fibres. Further studies are needed to confirm or rule out the presence of small fibre dysfunction in this fibromyalgia model.