Abstract Description
Institution: Nuffield Department of Clinical Neurosciences, University of Oxford - Oxford, United Kingdom
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with neuropathic pain. Chemogenetic tools have shown promise as a means to suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. We used PSAM4-GlyR to silence the activity of mouse sensory neurons. Furthermore, to show its potential for human therapeutic application, we expressed PSAM4-GlyR in human sensory neurons, where we used it to silence neuronal activity, as well as ectopic activity in a human cellular model of neuropathic pain.
Presenters
Authors
Authors
PhD Jimena Perez-Sanchez - Nuffield Department of Clinical Neurosciences, University of Oxford , DPhil Steven Middleton - Nuffield Department of Clinical Neurosciences, University of Oxford , PhD Mosab Ali Awadelkareem - Nuffield Department of Clinical Neurosciences, University of Oxford , PhD Alex Clark - Blizard Institute, Queen Mary University , MB PhD, FRCP, FMedSci David Bennett - Nuffield Department of Clinical Neurosciences, University of Oxford
