Neuropathic pain is a distressing condition commonly reported by breast cancer survivors. It often lasts for a long period of time even after cancer treatment completion. Susceptibility to pain have been reported to vary between individuals. Single nucleotide polymorphisms (SNPs) are known to play important roles in inter-individual variability to pain. We investigated the relationships between two major SNPs that were previously reported to be associated with neuropathic pain in breast cancer survivors: rs6265 (brain-derived neurotrophic factor; BDNF) and rs1800795 (interleukin 6; IL6). We found that each SNP contributed to women reporting worsening neuropathic pain scores, but a combined genotype of BDNF T/T x IL6 C/G showed the worst neuropathic pain scores among all the other genotypes investigated. These findings provide fundamental knowledge to identify and plan management strategies for women who are likely to experience neuropathic pain.