Poster overview: After spinal cord injury, peripheral nerve damage, or chemotherapy, primary nociceptors switch from an electrically silent to a hyperexcitable state that can result in the spontaneous firing of action potentials and chronic pain. This poster addresses two primary questions: 1) how general is persistent hyperactivity in nociceptor somata across persistent pain conditions, and 2) is there a single, all-or-none hyperactivity state with differing likelihoods of induction in different pain conditions, or do different conditions produce differing combinations of hyperactive alterations?