Microneurography is a clinically translatable in vivo electrophysiology technique that allows for the recording of cutaneous unmyelinated sensory fibers (c-fibers) that carry nociceptive signals. During chronic pain states, a subset of c-fibers displays spontaneous, ectopic firing that is believed to contribute to pain. Voltage-gated sodium channel 1.8 (Nav1.8) is believed to be important in mediating repetitive firing of these fibers. Therefore, inhibition of Nav1.8 is hypothesized to have therapeutic potential for chronic pain. We aimed to use the microneurography technique in non-human primates (NHPs) to record from c-fiber nociceptors and detect changes in excitability as a biomarker for target modulation by a novel, selective Nav1.8 inhibitor (Compound A).