Stress is a state of sensing actual or potential environmental threats and involves an adaptative response. Stressors may perpetuate the itch-scratch cycle in atopic dermatitis (AD), a chronic inflammatory skin condition characterized by intense and chronic pruritus, but some patients also report feeling pain with neuropathic characteristics. Stress exposure and the constant scratching behavior potentially may induce damage in small fibers and sensory alterations, including changes in pain symptomatology. We aim to determine the epidermal innervation of chronic lesions and the functional response of sensory fibers to acute stress in AD.