Biomedical science has made notable progress in the detection and treatment of cancer. Although greater survival rates have been achieved for many types of cancers, this is all too often accomplished with significant sacrifices in quality of life for our patients. Cancer-related neuropathic pain is a common debilitating sequela of cancer and its treatment.  Cancer-related pain results from either the malignancy itself or its treatment and it affects both patients on active treatment and long-term cancer survivors alike. Pain is the most common chief complaint upon ED presentation for patients with end-stage disease. Severe pain correlates with increased hospital readmissions, morbidity, and mortality. Among survivors, approximately 40% will experience chronic pain posttreatment, and 5% to 10% will have pain that interferes with daily living. Acute pain crises can be triggered by disease progression, tolerance to prescribed therapy, and suboptimal use of a prescribed regimen or can be provoked by ongoing systemic chemotherapy/radiotherapy. Nociceptive (visceral or somatic) and neuropathic pain mechanisms can present either independently or in combination.