Chronic postsurgical neuropathic pain (CPSNP) is a leading cause of neuropathic pain (NP). About 15-31% of patients undergoing surgical treatment of breast cancer report moderate to severe pain one year after surgery. The pain usually continues for years and is difficult to treat. The big question is why only a subset of surgical patients develop CPSNP after the same type of nerve injury. Most of the known factors associated with CPSNP are psychosocial or related to inflammation whereas molecular mechanisms are poorly understood. We therefore performed a transcriptome-wide profiling of two classes of non-coding RNAs (ncRNAs), miRNAs and circular RNAs (circRNAs), in a clinically well-defined cohort of breast cancer patients with a surgeon-verified injury of intercostobrachial nerve. We compared the expression of ncRNAs in subsets of patients with and without CPSNP to identify novel biomarkers for CPSNP. We also examined the causal relationship between differentially expressed miRNAs and circRNAs to investigate potential regulatory pathways and assessed the correlation of ncRNA expression with clinical symptoms. We identified 57 differentially expressed miRNAs in plasma and 3 circRNAs with altered expression in blood based on the presence or absence of CPSNP. Our findings support the existence of regulatory circRNA-miRNA-mRNA networks which might contribute to NP either directly by modulating pain or indirectly by regulating comorbid conditions and inflammation. Altered expression of circulating miRNAs and circRNAs in CPSNP patients supports their potential as diagnostic biomarkers while the predicted interactions between circRNAs and miRNA/mRNA targets might be utilized to develop novel therapeutics for NP.