Margot Maurer will present work focused on the mechanisms mediating sensory abnormalities in the passive transfer model of fibromyalgia (FM) in mice. Biochemical studies revealed an elevated accumulation of fibromyalgia patient IgG in murine tissues when compared to healthy control immunoglobulins. Interestingly, FM IgG was enriched in specific peripheral tissues, including sensory ganglia. Using transcriptomic approaches, gene expression changes were assessed in dorsal root and trigeminal ganglia during the development of fibromyalgia phenotype, leading to the identification of potential target candidate genes responsible for sensory dysfunction in FM. The impact of the transcriptional changes observed in passively transferred FM was then further investigated using electrophysiological and imaging techniques. Dr Maurer will discuss the potential mechanisms by which the observed transcriptional changes may alter sensory neuron excitability in the passive transfer model of fibromyalgia.